Brazilian-born Italian keyboard multi instrumentalist (piano, organ, harpsichord, and clavichord) Marco Orsini-Brescia started his musical education with his mother, Denise Orsini. He pursued his piano lessons with Clotilde Lobo de Rezende and Sergio Magnani and later with Vera Nardelli, who had a decisive influence on the twenty-year-old young man. He won the 10th National Piano Competition Arnaldo Estrella, a prime piano competition in Brazil.

In 2000, Orsini-Brescia moved to Spain after receiving a scholarship from the Spanish Government to participate in the international piano course of the Escuela Superior de Música Reina Sofia, given by Russel Sherman. The following year, he took part in the Daroca International Early Music Course, also in Spain, under the guidance of José Luis González Uriol, a crucial influence on his musical path, introducing him to the early music world and boosting his passion for ancient keyboard instruments and repertoire.

In 2013, he concluded his Ph.D. in Historical Musicology at the University Paris IV–Sorbonne, receiving the maximum grade, très honorable à l'unanimité. The same year, he earned a master's in Early Music/Historic organ performance at the Escola Superior de Música de Catalunya / Universitat Autònoma de Barcelona under the guidance of Javier Artigas, obtaining a highly regarded matrícula de honor. Orsini-Brescia performs in the most distinguished venues and international festivals in Europe, Central and South America. Since 2006, he has had an acclaimed duo with his wife, soprano Rosana Orsini, with whom he recorded the album ‘Angels and Mermaids: religious Music in Oporto and Santiago de Compostela (18th/19th century)’ (Arkhé Music, Portugal, 2016). The most prestigious international musical magazines praised his performance in the album ‘Zipoli in Diamantina: Complete Organ Works’ (Paraty, France, 2020), particularly highlighted by magazines Scherzo and Diapason. The Government of the State of Minas Gerais, Brazil, decorated him with the President Juscelino Kubitshek Medal of Honour.

Parallel to his musical activity, Orsini-Brescia is one of the most recognized musicologists in the field of Iberian organ studies, presenting lectures at international musicological meetings and publishing seminal works on this matter. Since 2019, he has been a researcher at the Faculty of Human Sciences/Universidade NOVA de Lisboa, where he is currently the coordinator of the group Music in the Modern Period/CESEM – Centre for Music Studies.